In this post, we’ll explore the top 6 injectable peptides for anti-aging, longevity, and mitochondrial health and my experience using each of them: NAD+, SS-31, MOTS-C, Epitalon, BPC-157, and TB-500. Aging is a natural process everyone experiences, but in recent years, scientific advancements have brought forward ways to slow it down, enhance longevity, and improve mitochondrial health. One promising area of research is the use of injectable peptides. These small chains of amino acids can profoundly affect the body, promoting healing, reducing inflammation, enhancing mitochondrial health, and even reversing signs of aging. Let’s dig in.
What are Mitochondria?
Mitochondria are the part of the cell responsible for producing energy in the form of adenosine triphosphate (ATP). Known as the cell’s powerhouse, they play a crucial role in energy production and overall cellular function. Our health is directly related to the health of our mitochondria. As we age, mitochondrial function tends to decline, contributing to aging and various age-related diseases. Injectable peptides have emerged as a promising intervention for enhancing mitochondrial health and promoting longevity.
Related Post: Read my article about injectable peptides’ side effects, benefits, and risks.
What are Peptides?
Peptides are molecules in our bodies that contain up to 50 amino acids joined by peptide bonds. They are the building blocks of proteins and are necessary for several vital cellular functions.
At least 7000 peptides are known to occur naturally in the body, and scientists have been studying them for over a century. Several have been recreated in a lab and utilized by the medical community. The first commercially available peptide in the US was insulin. More than 500 therapeutic peptides are being studied and used in health care today. Read more to discover the top six injectable peptides for mitochondrial health and longevity.
My Top Peptide Picks for Mitochondrial Health & Longevity
1. NAD+ (Nicotinamide Adenine Dinucleotide)
NAD+ is a coenzyme found in all living cells, playing a critical role in cellular metabolism and energy production. It is essential for the function of enzymes called sirtuins, which regulate cellular health and longevity. As we age, levels of NAD+ decline, leading to decreased cellular function and increased signs of aging.
Benefits of NAD+ for Anti-Aging and Mitochondrial Health
- Energy Production: NAD+ is crucial for converting nutrients into energy, which is vital for maintaining youthful energy levels.
- DNA Repair: NAD+ helps repair damaged DNA, preventing the accumulation of mutations that can lead to aging and disease.
- Cellular Health: By activating sirtuins, NAD+ promotes cellular health and longevity, reducing the effects of aging.
- Mitochondrial Function: NAD+ enhances mitochondrial function, ensuring efficient energy production and reducing mitochondrial dysfunction associated with aging.
How to Use NAD+
NAD+ can be administered intravenously or via subcutaneous injections. It’s important to follow the guidance of a healthcare professional to determine the appropriate dosage and frequency.
Clinical Evidence
Research on NAD+ is exciting, especially regarding its role in aging and keeping our metabolism healthy. Scientists have found that increasing NAD+ levels can significantly boost how our mitochondria work, help with insulin sensitivity, and support cellular repair. For example, a study published in Cell Metabolism showed that older adults who took NAD+ supplements had better muscle function and more mitochondria, the little powerhouses in our cells. Moreover, NAD+ helps activate sirtuins, which are proteins that keep our cells healthy and young. All these discoveries suggest that NAD+ could be a game-changer in slowing down aging and improving our overall health, making it a promising option for those looking to stay youthful and vibrant.
My Experience with NAD+
NAD+ is one of the more well-known injectable peptides that improve mitochondrial health and longevity. It’s the first injectable therapeutic I used over two years ago to boost my overall health. I did experience some temporary discomfort at the injection site, a slight, short-lived increase in heart rate, and mild stomach upset. On the bright side, I noticed better sleep, increased energy, and improved mental clarity.
2. SS-31 (Elamipretide)
SS-31, also known as Elamipretide, is a mitochondria-targeted peptide that helps to protect and repair mitochondrial function.
Benefits of SS-31 for Anti-Aging and Mitochondrial Health
- Mitochondrial Protection: SS-31 protects mitochondria from oxidative stress, maintaining their function and reducing cellular damage.
- Improved Cellular Function: By preserving mitochondrial health, SS-31 supports overall cellular function and vitality.
- Enhanced Energy Levels: Healthy mitochondria produce more energy, leading to increased vitality and reduced fatigue.
- Reduced Oxidative Stress: SS-31 mitigates oxidative stress within mitochondria, preventing damage and preserving mitochondrial DNA integrity.
Clinical Evidence
- SS-31 has shown promise in clinical trials for conditions like primary mitochondrial myopathy and heart failure.
- It may improve muscle function and reduce frailty in elderly individuals.
- Potentially offers protection against neurodegenerative diseases by preserving mitochondrial health in neurons.
- Its ability to improve mitochondrial function and reduce oxidative stress positions it as a powerful candidate for longevity therapies.
How to Use SS-31
SS-31 is typically administered through subcutaneous injections. A healthcare provider should determine the dosage and frequency based on individual needs.
My Personal Experience with SS-31
I’ve had a great experience injecting SS-31, a peptide that helps repair mitochondria. The best part is that there are no adverse side effects! Instead, I’ve noticed amazing positive effects like better sleep, increased energy, and improved brain fog. Since it works at the cellular level, the improvements may not be immediately apparent, but they’re there. This was the first peptide that my sister tried, and she’s been using a CGM to monitor her blood sugar and a Lumen device to keep track of her metabolic health. It’s been incredible to see that after just a few daily doses of SS-31, she’s been waking up in “fat-burning mode” every single day for the first time in 7 months.
3. MOTS-C
MOTS-C is a mitochondrial-derived peptide that regulates metabolic functions and cellular energy production. It has been shown to improve metabolic health and has potential anti-aging effects.
Benefits of MOTS-C for Anti-Aging and Mitochondrial Health
- Metabolic Regulation: MOTS-C improves insulin sensitivity and metabolic function thereby protecting against Type 2 Diabetes, which can decline with age.
- Enhanced Longevity: Studies suggest that MOTS-C can extend lifespan by improving mitochondrial function and reducing oxidative stress.
- Weight Management: By regulating metabolism, MOTS-C can help maintain a healthy weight and enhance physical performance and muscle function, which is crucial for longevity.
- Mitochondrial Biogenesis: MOTS-C promotes the formation of new mitochondria, enhancing cellular energy production and overall mitochondrial health.
How to Use MOTS-C
MOTS-C is usually administered via subcutaneous injection. A healthcare professional can guide the correct dosage and administration schedule.
Clinical Evidence
At present, research on MOTS-c is still in the early stages, but animal studies have shown that it can improve metabolic health and extend lifespan in mice. Be that as it may, human studies are needed to confirm these findings, but the potential is substantial.
My Personal Experience with MOTS-C
I’ve had some experience with injecting MOTS-C, which is known to enhance the functioning of mitochondria. The best part is that there are no negative side effects. In fact, I noticed some positive effects like improved sleep, increased energy levels, and even shedding a few pounds. However, since it works on a cellular level, the improvements may not be immediately noticeable.
4. Epithalon (Epitalon)
Epitalon is a synthetic peptide that mimics the action of a naturally occurring peptide called Epithalamin. It has been studied for its potential to regulate the aging process and extend lifespan by influencing the production of telomerase, an enzyme that maintains the length of telomeres, the protective caps on the ends of chromosomes that shorten with age.
Benefits of Epitalon for Anti-Aging and Mitochondrial Health
- Telomere Lengthening: Epitalon stimulates the production of telomerase, which helps maintain the length of telomeres, protecting chromosomes from damage and slowing the aging process.
- Improved Sleep: Epitalon regulates melatonin production, promoting better sleep quality, which is essential for overall health and longevity.
- Immune System Support: By modulating the immune system, Epitalon helps maintain immune function, which often declines with age.
- Mitochondrial Function: Epitalon supports mitochondrial health by promoting the expression of genes involved in mitochondrial function and biogenesis.
- Reduces Oxidative Stress: Epitalion protects against mitochondrial damage by reducing oxidative stress and inflammation.
How to Use Epitalon
Epitalon can be administered via subcutaneous injection or as a nasal spray. A healthcare professional should customize the treatment protocol, including dosage and duration.
Clinical Evidence
Epitalon has been studied in animal models and some human trials, showing promising results in extending lifespan and improving markers of health. Its ability to enhance mitochondrial function and reduce oxidative stress makes it a strong candidate for longevity therapies.
My Personal Experience with Epitalon
Unquestionably, one of my favorite peptides so far is Epitalon. I administered it to help with the immune system, sleep, and slowing down aging. On a positive note, there were no harmful side effects at all. While taking it, I noticed better sleep, more energy, improved memory, and clearer thinking. As with the others, the changes might take time to see since it works on a cellular level.
5. BPC-157 (Body Protection Compound-157)
BPC-157 is a synthetic peptide derived from a protein found in the stomach. It is renowned for its powerful healing properties, particularly for muscles, tendons, and ligaments.
Benefits of BPC-157 for Anti-Aging and Mitochondrial Health
- Tissue Repair: BPC-157 accelerates the healing of various tissues, promoting recovery from injuries and reducing the wear and tear associated with aging.
- Anti-Inflammatory Effects: By reducing inflammation, BPC-157 helps to prevent chronic inflammatory conditions that can accelerate aging.
- Gastrointestinal Health: BPC-157 supports the health of the gut lining, which is crucial for overall health and longevity.
- Mitochondrial Protection: BPC-157 promotes mitochondrial health by reducing oxidative stress and supporting mitochondrial repair processes.
- Cellular Energy Production: BPC-157 improves overall vitality and reduces fatigue by enhancing cellular energy production.
- Brain Health: Protects against neurodegenerative diseases by maintaining mitochondrial function in brain cells.
How to Use BPC-157
BPC-157 is commonly administered via subcutaneous injections, often near the injury site. The dosage and administration frequency should be tailored to individual needs under the supervision of a healthcare provider.
Clinical Evidence
Animal studies have demonstrated that BPC-157 can protect against mitochondrial dysfunction induced by various toxins and stressors. Although human clinical trials are still in the early stages, anecdotal reports and preliminary findings are promising.
My Personal Experience with BPC-157
I tried using BPC-157 to reduce inflammation, heal tissue, and boost gut health. There were no adverse effects. I decided to take it after a strenuous hike, which left my foot and hip hurting. Just an hour after taking it, all my pain disappeared, and I felt amazing.
6. TB-500 (Thymosin Beta-4)
TB-500 is a synthetic version of a naturally occurring peptide called Thymosin Beta-4. It is known for its regenerative properties and ability to promote healing and tissue repair. It is often used in combination with BPC-157.
Benefits of TB-500 for Anti-Aging and Mitochondrial Health
- Wound Healing: TB-500 promotes the formation of new blood vessels (angiogenesis), which enhances nutrient and oxygen delivery to tissues. Consequently, this promotes wound and injury healing, which is particularly beneficial as the body’s ability to repair itself diminishes with age.
- Tissue Regeneration: It promotes the regeneration of tissues, including muscles and ligaments, helping to maintain physical function and mobility.
- Anti-Inflammatory Properties: TB-500 reduces inflammation and oxidative stress, helping to prevent chronic conditions that contribute to aging.
- Mitochondrial Biogenesis: TB-500 supports the formation of new mitochondria, enhancing cellular energy production and overall mitochondrial health.
How to Use TB-500
TB-500 is typically administered via subcutaneous injections. Of course, a healthcare professional should determine the dosage and treatment duration based on individual needs.
Clinical Evidence
TB-500 has been studied primarily for its role in wound healing and tissue repair. While direct evidence of its impact on longevity is limited, its ability to enhance mitochondrial function and reduce inflammation suggests significant potential.
My Personal Experience with TB-500
My time trying out TB-500 was great. It helped reduce inflammation and promote tissue repair without any adverse side effects. That said, since I already used BPC-157, I didn’t notice any significant changes with TB-500 alone. However, when I combined them, I felt a more substantial anti-inflammatory effect on my achy joints and muscles.
My Peptide Journey
I have been using these peptides in the sequence I am presenting today. Initially, I began with NAD+ as it was accessible at my workplace a few years back. Subsequently, I delved into my injectable peptide regimen with SS-31, known for its ability to repair damaged mitochondria. Following that, I incorporated MOTS-C and Epitalon, both known for enhancing mitochondrial function.
The potential benefits of injectable peptides for mitochondrial health and longevity are reason enough for me to try them. I have found experimenting with various peptides beneficial for my well-being, and I plan to share my experiences with others, including AOD-9604, CJC-1295, and Ipamorelin.
Final Thoughts
The peptides NAD+, BPC-157, SS-31, MOTS-c, TB-500, and Epitalon are at the forefront of cutting-edge research to improve mitochondrial health and extend lifespan. As I have said, it is essential to consult a healthcare professional before considering their use, as more research is needed to determine their long-term effects and optimal dosing. By incorporating these peptides into a holistic approach to health, alongside a balanced diet, regular exercise, and other lifestyle factors, we can maximize their potential benefits for longevity and mitochondrial function as we age. The future of longevity science looks promising, with these innovative peptides leading the way.
Share Your Experience With Me
I’d love to hear from you! Do you have experience using injectable peptides? Are you curious if they can help you? Does utilizing injectable peptides for mitochondrial health and longevity interest you? Please feel free to comment down below.
Shop This Post
THIS POST CONTAINS AFFILIATE LINKS, WHICH MEANS I MAKE A SMALL COMMISSION AT NO EXTRA COST TO YOU. FOR THE FULL PRIVACY POLICY, CLICK HERE. THANK YOU FOR SUPPORTING MY SMALL BUSINESS!
Pin It For Later
Love you and how you are sharing your journey with us! Thank you!!